Our research focuses on the mechanics of biological systems at the cellular, intracellular, and molecular level. We develop new techniques, mainly based on micropipettes coupled to microscopy. We also like to paint cellular processes.
Keywords: Atherosclerosis, Cancer, Cell Mechanics, Endothelial Cells, Force Generation, Immunological Synapse, Leukocytes, Membranes, Microindentation, Micropipettes, Microscopy, Microtubules, Mitochondria, Rigidity Sensing, T lymphocytes, Transendothelial Migration.
Molecular Biology of the Cell, 2017 ( in press). Micropipette Force Probe to quantify single-cell force generation: application to T cell activation. A. Sawicka, A. Babataheri, S. Dogniaux, A. I. Barakat, D. Gonzalez-Rodriguez, C. Hivroz, and J. Husson.
Biophysical Journal, 20 Dec 2016; 111(12):2711-2721. D. Gonzalez-Rodriguez*, L. Guillou*, F. Cornat, J. Lafaurie-Janvore, A. Babataheri, E. de Langre, A. I. Barakat, and J. Husson. Mechanical criterion for the rupture of a cell membrane under compression.
Molecular Biology of the Cell 2016; 27(22): 3574-3582. Guillou L, Babataheri A, Saitakis M, Bohineust A, Dogniaux S, Hivroz C, Barakat AI, and Husson J. T lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs (journal cover, see below).
Biophysical Journal, 1 Nov 2016; 111(9): 2039-2050. Lionel Guillou*, Joanna B. Dahl*, Jung-Ming G. Lin*, Abdul I. Barakat, Julien Husson, Susan J. Muller, Sanjay Kumar. Measuring cell viscoelastic mechanical properties using a microfluidic extensional flow device.
Cell, 24 March 2016;165(1):100-110. Basu R*, Whitlock BM*, Husson J*, Le Floc’h A, Jin W, Dotiwala F, Giannone G, Hivroz C, Lieberman J, Kam LC, and Huse M. (* co-first authors). Cytotoxic T cells use mechanical force to potentiate target cell killing.